Pseudodifferential operators on Euclidean space $\mathbf R^n$ are studied. These operators, whose definition must be modified in a natural way, act in Hilbert spaces with weighted norms. Using the Mellin transform, a pseudodifferential operator on the sphere $S^{n-1}$ (actually a meromorphic function of a complex parameter $\lambda$ ) is assigned to an operator on $\mathbf R^n$ . This permits one to reduce the study of an algebra of operators on $\mathbf R^n$ to the investigation of an algebra of meromorphic operator-valued functions on $S^{n-1}$ . This paper consists of four sections. In § 1 preliminaries are presented. The second section is devoted to the study of an algebra of meromorphic operator-valued functions on the sphere$S^{n-1}$. In § 3 an algebra of pseudodifferential operators on$\mathbf R^n$is considered. The last section contains rules for change of variables in operators on the sphere and on$\mathbf R^n$.Bibliography: 5 titles.